Doctor's Best Benfotiamine is a fat-soluble form and highly bioavailable derivative of thiamin (Vitamin B1). Benfotiamine is activated in the bloodstream, and is available in the body four times longer than water-soluble thiamin. Benfotiamine activates transketolase, a cellular enzyme essential for glucose metabolism pathway. It helps support the circulatory and nervous systems with radical-scavenging action against oxidative stress, providing a positive influence on Advanced Glycation End products (AGEs).