Gcm + Uc-ii is a unique combination of four joint support nutrients: Glucosamine, Chondroitin, Msm, and Uc-II4 ingredient. A small amount, 40mg of Uc-ii has been found to promote joint comfort permitting Doctor's Best to create a smaller, easier to swallow capsule, what we call a ""maintenance"" dose. Double-blind, placebo controlled clinical studies have shown that a daily dose of 40mg of Uc-ii supplementation is both safe and effective in supporting joint comfort.